Effect Of Methanolic Leaves Extract of Telfairia occidentalis on 2,4-Dinitrophenylhydrazine Induced Anaemic Rats

  • *Suleiman, Z.A., Salahuddeen, Y. and Sabiu, U.A.

  • UJMR 2022, 7(1), Pp 71 - 74, DOI:  10.47430/ujmr.2271.011


Anaemia constitutes a serious health problem in many tropical countries including Nigeria because of the high prevalence of malaria and other parasitic infections which possibly leads to a decrease in hemoglobin. Fluted pumpkin has been reported to be very good in building the constituents of the blood and replacing them. This study investigated the effects of the methanolic leaves extract of fluted pumpkin on some hematological parameters in 2, 4-dinitrophenylhydrazine-induced anaemic rats. Thirty Wister rats of both sexes were separated into five groups of six rats each. Group 1 serves as normal control, while groups 2-5 were induced with anaemia using 40mg/kg body weight of 2,4- dinitrophenylhydrazine. Group 2 serves as the negative control without treatment, group 3 were given 20 mg/kg (b.w) of standard hematinic drug astymin, and group 4 and 5 were administered with 200 and 400 mg/kg w/w methanolic leaves extract of Telfairia occidentals respectively. All rats were fed with grower’s mash and water ad libitum for 21 days. The rats were sacrificed, and blood samples were collected for hematological analysis. All analysis was done using standard methods. The result of this study demonstrated that oral administration of 200 mg/kg and 400mg/kg of the extract increased the haematological parameters under investigation. A significant (p<0.05) increase in haematinic activity was observed in group 3 and 5, and it was concluded that methanolic leaves extract of fluted pumpkin could be effective in ameliorating anaemia.

Keywords: Anemia; Telfairia occidentalis; 2, 4-dinitrophenylhydrazine; Haematological

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The Editorial Board of UJMR is glad to have published the Twelfth edition (Volume 7 Number 1, June, 2022). The Journal covers general and Applied Microbiology, Biotechnology, Biological Sciences, Biochemistry, Bioinformatics, Medical, Public Health and Environmental sciences.

This year, UMYU Journal of Microbiology Research (UJMR) has reached its 5th year of publication which started in 2016. Over these years, many changes have been made to the typeface and general formats of the manuscripts, both the print version and online copies, to make the Journal meet the international standard and more visually appealing. From volume 3 (2) onward, all the online copies of UJMR papers on our website have been uploaded with their full colours. In addition, both authors and co-author are issued with e-certificates of publication for their respective published manuscripts.

We are glad that UJMR is gaining wider acceptance within Nigeria and in some foreign countries, and the number of submissions to the Journal is increasing. Despite the increase in manuscripts, UJMR maintained its quality as reflected by the rigorous peer-reviewing process. All articles submitted are accepted for publication based on a fair, objective, and anonymous assessment by our editors backed by the cogent decision by the editorial board. UJMR has thus increased the number of her associate editors by bringing in more people from academia who are experts in various fields within the scope of the Journal to enhance/maintain the speedy review of manuscripts received from various authors. The UJMR website has been upgraded so that UJMR readers and authors could get vital services such as online submission of manuscripts, downloading UJMR archives, author guidelines, etc.

UJMR’s vision is to be an internationally recognised premier journal of Microbiology, to contribute toward high-quality research and dissemination of UJMR to reach a larger audience worldwide. The journal is now indexed with reputable indexing organizations such as Crossref, Index Corpernicus International, International Institute of Organized Research (I2OR), Google Scholar, CiteSeerX, among others. In addition, the Journal has scored a publication impact factor of 2.525 for the year 2020 and Index Corpernicus value (ICV) of 85.02. Moreover, all our published articles are now assigned DOI. We hope that anyone with the expertise would join us and collaborate with our effort to obtain a much higher Impact Factor. We are delighted that UJMR is the first University-based microbiology journal in Nigeria. Therefore, we urge our academic colleagues to join hands with us towards projecting scientific research.

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Dr. Bashir Abdulkadir

Editor – in – Chief       

Abstracting and Indexing