Evaluation of Susceptibility Profiles of Some Bacteria to Flouroquinolones in Kano Metropolis, Nigeria
DOI:
https://doi.org/10.47430/ujmr.2051.005Keywords:
flouroquinolones,, clinical bacterial isolates,, sensitivity and resistance profiles.Abstract
Resistance to broad spectrum antibiotics such as flouroquinolones by bacteria is becoming a major threats towards the chemotherapy of some common pathogenic bacterial infections in the world especially the developing nations. In view of that, susceptibility profiles of some pathogenic bacteria to some flouroquinolones were evaluated using modified Kirby-Bauer Disc Diffusion Technique. Four flouroquinolones antibiotics; ofloxacin and ciprofloxacin (second generation), levofloxacin (third generation), moxifloxacin (fourth generation) were tested on five bacterial species (Staphyllococcusaureus, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis and Klebsiella pneumoniae) sourced from Aminu Kano Teaching Hospital, Kano, Nigeria, and re-confirmed at Microbiology Laboratory in Bayero University, Kano. The results of the study revealed that 8(26.7%) of E. faecalis isolates were sensitive levofloxacin, 6(20.0%) were saensitive to ciprofloxacin and 1(3.33%) were sensitive to ofloxacin, while 0(0.00%) was sensitive to moxifloxacin. Seven isolates (23.3%) of S. aureus were sensitive to levofloxacin, 15(50.0%) were sensitive to ciprofloxacin and 4(13.3%) were sensitive to ofloxacin, while none (100%) were sensitive to moxifloxacin. E. coli isolates were 96.6% resistant to levofloxacin, Klebsiella pneumoniae and P. aeruginosa isolates exhibited 76.6 and 50.0% resistance to the antibiotic respectively. There was significant difference in the performance of the four antibiotics used, ciprofloxacin better than others (p-value 0.00604). There was no significant difference in the percentages of sensitive bacterial species to the antibiotics used in the research (p-value 0.614), however, P. aeruginosa showed relatively higher number of sensitive isolates 30(40%). It can be concluded that 58% of the isolates were moderately sensitive to all the antibiotics in this study.
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