Antimicrobial activity of Bis-salicylaldehyde Ethylenediamine Schiff Base and Its Lanthanoids (III) Complexes
DOI:
https://doi.org/10.47430/ujmr.2272.013Keywords:
Bis-salicylaldehyde ethylenediamine, Schiff base, Lanthanoids, antibacterial, antifungal, activityAbstract
Schiff base readily form complex with metal ions and the resultant complexes especially from transition metals were extensively used in many fields of human endeavor including antimicrobial therapy. However, the potentials of Lanthanide-Schiff base complexes as an antimicrobial agent have not been adequately studied. This study aims to synthesize and determine the antimicrobial activity of Bis-salicylaldehyde ethylenediamine Schiff Base and its Lanthanoids (III) Complexes. The Dysprosium (III), Gadolinium (III), Neodymium (III) and Samarium (III) complexes of Schiff base derived from Salicylaldehyde and ethylenediamine were synthesized under reflux condition in ethanol and their antimicrobial activity were determined using disc diffusion method. Bis-salicylaldehyde ethylenediamine was a shiny crystalline yellow with a yield of 93% and its complexes were various sheds of yellow ranges from pale to dark, with percentage yield between 94-98%. The Bis-salicylaldehyde ethylenediamine had good activity against C. albican (32mm at 100mg/ml), A. niger (20mm at 100mg/ml) and Fusarium Spp (17mm at 100mg/ml) but its complexes had low (07-11mm at 100mg/ml) or no (06mm at 100mg/ml) activity against all the fungal isolates. The antibacterial activity of the Bis-salicylaldehyde ethylenediamine against E. coli (8mm at 100mg/ml), Pseudomonas (6mm at 100mg/ml) and Klebsiella (13mm at 100mg/ml) was lower than that of Ampiclox (between 17 to 20mm) and even though, all its Lanthanoid (III) complexes between 8 to 14mm at 100mg/ml) had higher antibacterial activity than the Bis-salicylaldehydeethylenediamine but still the activity of Lanthanoid (III) complexes was lower than that of Ampiclox. Considering the in-vitro antimicrobial activity exhibited by Bis-salicylaldehyde ethylenediamine and its Lanthanoid (III) complexes against bacterial and fungal isolates, both will not be potential antibacterial agent but Bis-salicylaldehyde ethylenediamine could be pontential antifungal agent. We therefore, recommend further researches geared toward exploring its full potentials for antifungal therapy.
Downloads
References
Anjaneyulu, Y., Murthy, L.N., and Rao, R. P., (1986). Prepation , characterization and antimicrobial activity studies on some ternary complexes of Cu(II) with acetylacetone and various salicylic acids," Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry,. Research Journal of Pharmaceutical, Biology and Chemical Sciences, 16(2), 257-272. https://doi.org/10.1080/00945718608057530
Correa-ascencio, M., Galvan-Miranda, E. K., Rascon-Cruz, F., Jimenez-Sandoval, O., Jimenes-Sandoval, S. J., Cea-olivares, R., and Gracia-Montalvo, V., (2010). Lanthanide(III) Complexes with 4,5-Bis(diphenylphosphinoyl)-1,2,3-triazole and the Use of 1 , 10-Phenanthroline As Auxiliary Ligand. Inorganic Chemistry Communications, 49(18), 4109-4116. https://doi.org/10.1021/ic902120e. https://doi.org/10.1021/ic902120e
Gopu, P. and Xavier, A., (2015). Synthesis and Characterization of 4- ( 3-bromo-5- chloro-2-hydroxybenzlidimino ) Benzoic Acid and its Transition Metal Complexes. International Journal of Science and Research(IJSR), 4(8), pp.1491-1495.
Kendre, K.L., Pande, G. and Pingalkar, S.R., (2014). Synthesis and characterization of lanthanide complex derived from tetradentate schiff base and it ' s antimicrobial activity. Der Chemica Sinica, 5(4), pp.12-16. Leandro, Eliene. De Araújo, Franciane, Hellen. Goncalves, Barbosa. Ralph, Edward, Dockal
Tadeu, Éder. and Gomes Cavalheiro., (2017). Synthesis, characterization and biological activity of Cu ( II ), Ni ( II ) and Zn ( II ) complexes of biopolymeric Schiff bases of salicylaldehydes and chitosan. International Journal of Biological Macromolecules, 95, pp.168-176. https://doi.org/10.1016/j.ijbiomac.2016.10.109
Lekha, L. (2014). Studies on the synthesis , characterisation and antimicrobial applications of rare earth metal. (D. D. Easwaramoorthy, Ed.) (First).
Mikhalyova, Elena. A, Yakovenko, Anastasiya. V, Zeller, Matthias. Gavrilenko, Konstantin, S. Lofland, Samuel. E, Addison, Anthony. W, and Pavlishchuk, Vitaly, V., (2014). Inorganica Chimica Acta Structure , magnetic and luminescence properties of the lanthanide complexes Ln 2 ( Salphen ) 3 Á H 2 O ( Ln = Pr , Nd , Sm , Eu , Gd , Tb ,. INORGANICA CHIMICA ACTA, 414, pp.97-104. Available at: http://dx.doi.org/10.1016/j.ica.2014.01.034. https://doi.org/10.1016/j.ica.2014.01.034
Naini, Y., Ahmad, T. J., Kouassi, G. K., Ananda, S., and Gowda, Netkal. M. Made., (2012). Synthesis and Characterization of Transition Metal Complexes of Chlorpromazine. American Journal of Chemistry, 2(4), 181-185. https://doi.org/10.5923/j.chemistry.20120204.01
Nworie, F. S., (2016). Bis ( Salicylidene ) Ethylenediamine ( Salen ) and Bis ( Salicylidene ) Ethylenediamine-Metal Complexes : from Structure to Biological Activity. Journal of Analytical and Pharmaceutical Research, 3(6), 1-10. https://doi.org/10.15406/japlr.2016.03.00076.
Pradhan, A., and Kumar, A., (2015). A Review : An Overview on Synthesis of Some Schiff bases and there Metal Complexes with Anti-Microbial Activity. Chemical and Process Engineering Research, 35(Ii), 84-87.
Prafullkumar, A. kulkarni., Seema, I. Habib., Devdatta, V. Saraf.,and Mrunalini, M. Deshpande., (2012). Research Journal of Pharmaceutical , Biological and Chemical Sciences Synthesis , Spectral Analysis and Antimicrobial Activity of some new transition metal complexes derived from 2 , 4-dihyroxy acetophenones. Research Journal of Pharmaceutical, Biology and Chemical Sciences, 3(1), 107-113.
Rehman, M., Imran, M., and Arif, M., (2013). Synthesis , Characterization and in vitro Antimicrobial studies of Schiff-bases derived from Acetyl acetone and Amino acids and their Oxovanadium ( IV ) complexes. American Journal of AppliedChemistry, 1(4), 59-66. https://doi.org/10.11648/j.ajac.20130104.13.
Sani, S., and Kurawa, M. A., (2016). Synthesis , Characterization and Antimicrobial Studies of Mn ( II ) Complex With N-Salicyl-O-Hydroxyphenyleneiminato Schiff Base Ligand. ChemSearch Journal, 7(2), 28-33.
Santhi, S. and Radhakrishnan, N. and C.G., (2013). Synthesis , Characterization andAntimicrobial Activity of Schiff Base Ligand Complexes of Sm ( III ), Gd ( III ) and Dy ( III ) ions. International Journal of Chem Tech Research, 5(4), pp.1750-1755.
Shafaatian, Bita, Ozbakzaei, Zahra, Notash, Behrouz and Rezvani, S. Ahmad., (2015). Synthesis, characterization, single crystal X-ray determination, fluorescence and electrochemical studies of new dinuclear nickel(II) and oxovanadium(IV) complexes containing double Schiff base ligands. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 140, pp.248-255. Available at: http://dx.doi.org/10.1016/j.saa.2014.11.108. https://doi.org/10.1016/j.saa.2014.11.108
Sharma, K., Swami, M., Singh, R., Fahmi, N. and Singh, R. V., (2009). "Coordination chemistry of palladium(II) and Platium(II) complexes with bioactive Schiff bases: Synthetic, spectral, and biocidal aspects" Russian Journal of Coordination Chemistry,. Journal of Advanced Research, Vol.35(2), pp142-148. https://doi.org/10.1134/S1070328409020092
Singh, P., and Dhakarey, Rajesh. K. S., (2009). Synthesis , characterization and antimicrobial studies of metal complexes with schiff bases derived from 2-thienyl glyoxal. RASAYAN J.Chem, 2(4), 869-874.
Usharani, M.Akila, E, Ashokan, R and Rajavel, R., (2013). Pharmacological properties of Schiff base Metal complexes derived from substituted pyridine and aromatic amine. International Journal of Pharmaceutical Sciences and Health Care, 5(3), pp.1-11.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 UMYU Journal of Microbiology Research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
