Antidiabetic Properties of Aqueous Leaf and Stem Extracts of Andrographis paniculata on Alloxan Induced Diabetes in Wistar Rats
DOI:
https://doi.org/10.47430/ujmr.2271.010Keywords:
Diabetes mellitus, Andrographis paniculata, Wistar rat, Blood sugarAbstract
Diabetes mellitus is a disorder in which the body does not produce enough or respond normally to insulin, causing blood sugar (glucose) levels to be abnormally high. The aim of the study was to assess the effectiveness of Andrographis paniculata leaf and stem bark extracts in management of Alloxan induced diabetes Wistar rats. Fifty (50) Wistar rats were divided into eight groups, namely; group A (normal control), B, C, D, E, F, G and H (treatment groups). The study was conducted for four (4) weeks by measuring blood glucose levels in first four weeks. The result showed that the diabetic rats administered with 500mg/kg of aqueous leaf extract and 250mg/kg of stem bark extract were significantly lower than those of untreated control groups. However, the combined dose of 250mg/kg aqueous leaf and 250mg/kg stem extracts were not significantly different from untreated control group. Findings of the study have demonstrated that leaves and stem extract of A. paniculata exhibited significant blood sugar lowering property in Alloxan induced diabetic Wistar rats.
Downloads
References
Adedapo, A.A., Adeoye, B.O., Sofidiya, M.O., and Oyagbemi, A.A. (2014). Antioxidant, antinociceptive and anti-inflammatory properties of the aqueous and ethanolic leaf extracts of Andrographis paniculata in some laboratory animals. Journal of Basic Clinical Physiology and Pharmacology. DOI 10.1515/jbcpp-2014-0051. 10(2):25-27.
Akbar, S., (2011). "Andrographis paniculata: a review of pharmacological activities and clinical effects," Alternative Medicine Review, 16 (1): 66-77.
Borgohain, P. and Kakoti, B.B. (2019). Study of acute toxicity and anti-inflammatory activity of Andrographis paniculata Nees (Acanthaceae). International Journal of Science, Environment and Technology; 8(3): 580 - 584
Burkill, I. H., Birtwistle, W., Foxworthy, F., Scrivenor, J., and Watson, J., (1966). A Dictionary of the Economic Products of the Malay Peninsula, Ministry of Agriculture and Co-operatives, Kuala Lumpur, Malaysia. 57-59
Chaudhary, G., Goyal, S., and Poonia, P., (2010). "Lawsonia inermis Linnaeus: a phytopharmacological review," International Journal of Pharmaceutical Sciences and Drug Research, 2(2): 91-98.
Dahiru T, Aliyu AA, Shehu AU. (2016). A review of population-based studies on diabetes mellitus in Nigeria. Sub-Saharan African Journal of Medicine; 3:59-64.
https://doi.org/10.4103/2384-5147.184351
Etuck, E.U., Mohammed, B.J. (2010), Evidence based analysis of Chemical Method of Induction of Diabetes mellitusin experimental animal, Asian Journal of Experiment and Biological Science 1(2):331-336.
Emordi J.E., Agbaje E.O., Oreagba I.A., and Iribhogbe O.I. (2018). Antidiabetic Effects of the Ethanolic Root Extract of Uvariachamae P. Beauv (Annonaceae) in Alloxan-Induced Diabetic Rats: A Potential Alternative Treatment for Diabetes Mellitus. Hindawi Advances in Pharmacological Sciences
https://doi.org/10.1155/2018/1314941
Volume 2018, Article ID 1314941, 13 pages https://doi.org/10.1155/2018/1314941.
https://doi.org/10.1155/2018/1314941
Hajiaghaee, H., and Akhondzadeh, S., (2012). "Herbal medicine in the treatment of Alzheimer's disease," Journal of Medicinal Plants, 11 (41): 1-7.
International Diabetes Federation. Diabetes Atlas. 9th ed. Brussels: International Diabetes Federation; 2019. Available from: www.diabetesatlas.org. [Last accessed on 2021 Mar 237]
Kabir, M. H., Hasan, N., Rahman, M. M., (2014). "A survey of medicinal plants used by the Deb barma clan of the Tripura tribe of Moulvibazar district, Bangladesh," Journal of Ethnobiology and Ethnomedicine, 10 (1): 19.
https://doi.org/10.1186/1746-4269-10-19
Kavishankar, G., Lakshmidevi, N., Murthy, S. M., Prakash, H.., and Niranjana, S., (2011) "Diabetes and medicinal plants-a review," Journal of Pharmaceutical and Biomedical Sciences, 2, (3): 65-80.
Lorke, D., (2003). A new approach to practical Acute Toxicity Testing. Achieves of Toxicology 54(4): 275-287.
https://doi.org/10.1007/BF01234480
Ojewole, (2003). Laboratory Evaluation of Hypoglycemic effect of Anacardium accidentalelinn (Anacardiaceae) stem-bark extracts in rats. Methods of Final Experiment of Clinical Pharmacology 25(3): 199-204.
https://doi.org/10.1358/mf.2003.25.3.769640
Onyenekwe B.M., Young E.E., Nwatu C.B., Okafor C.I., Ugwueze C.V., Onuekwusi K.O. (2019). Diabetes Mellitus in adult Nigerians: patients' characteristics, laboratory profile, practices and management outcome. International Journal of Research in Medical Sciences; 7(10):3844-3853. http://dx.doi.org/10.18203/2320-6012.ijrms20194320
https://doi.org/10.18203/2320-6012.ijrms20194320
Shahid, A., (2011). Andrographis paniculata: A review of pharmacological activities and clinical effects. Alternative Medicine Review; 16:66-77.
Sivakumar V., Rajeshkumar S. (2015): Protective effect of Andrographis paniculata on hyperglycemic mediated oxidative damage in renal tissues of diabetic rats. The Journal of Phytopharmacology 4(6): 287-294.39.
https://doi.org/10.31254/phyto.2015.4603
Victor, N.O., Obiora, A., Egba, S.I., and Ikechukwu, U.R. (2017). Modulation of blood glucose concentration, lipid profile and haematological parameters in alloxan induced diabetic rats using methanol extract of Nauclealatifolia root bark. Asian Journal of Biological Science; 10: 1-8
https://doi.org/10.9734/AJOB/2017/34291
Worasuttayangkurna, L., Nakareangrit, W., Kwangjaic, J., Sritangosa, P., Pholphanaa, N., Watcharasita, P., Rangkadiloka, N., Thiantanawata, A., Satayavivad, J. (2019). Acute oral toxicity evaluation of Andrographispaniculata-standardized first true leaf ethanolic extract. Toxicology Reports; 6: 426-430; https://doi.org/10.1016/j.toxrep.2019.05.003.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 UMYU Journal of Microbiology Research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
