Phytochemicals and Haematological Studies of Aqueous Crude Extract of Whole Plant of Euphorbia heterophylla Administered to Wistar Albino Rats
DOI:
https://doi.org/10.47430/ujmr.2382.024Keywords:
Phytochemical, Haematological studies, Aqueous extract, Euphorbia heterophylla, Wistar Albino ratsAbstract
Changes in blood parameters are often triggered when toxic doses of plant extracts are administered to animals thereby calling for the haematological studies. Standard techniques were used for the phytochemical and haematological studies. Tannins, steroids, cardiac glycosides, flavonoids, alkaloids, terpenoids, phenols, reducing sugars and saponins were found in the aqueous crude extract obtained from Euphorbia heterophylla. Dosage increment of the aqueous extract from 10-600 mg/kgbw led to increments in all the haematological parameters (Total white blood cell, red blood cell, packed cell volume, red blood indices, platelets and differential white blood cell) checked in the blood of the experimental Wistar albino rat.The implication of this study is that the extractcan be used as therapeutic agents and the haematological parameters were dose-dependent.
Downloads
References
Abalaka, M. E., Akpor, O. B., Bello, A. B., Olonitola, O. S., Sani, A. & Osemwegi, O. O. (2016). Synthesis of Silver Nanoparticles (AgNPs) from Bark and Root of African Mahogany (Khaya Senegalensis) and The Comparative Studies of their Antimicrobial Properties. Asian Journal of Microbiology and Biotechnology, 1 (1): 25-32. https://doi.org/10.47430/ujmr.1611.007
Ajuru, M. G., Williams, L. F. & Ajuru, G. (2017). Qualitative and Quantitative Phytochemical Screening of Some Plants Used in Ethnomedicine in the Niger Delta Region of Nigeria. Journal of Food and Nutrition Sciences, 5 (5): 198-205. https://doi.org/10.11648/j.jfns.20170505.16
Akomas, S. C., Ijioma, S. N. & Emelike, C. U. (2015). Effect of Euphorbia hirta on Haematological and Biochemical Indices in Albino Rats. Applied Journal of Hygiene, 4 (1): 01-05. https://doi.org/10.5829/idosi.ajh.2015.4.1.9276
Arome, D. & Chinedu, E. (2013). The importance of toxicity testing. Journal of Pharmaceutical and Biosciences, 4 (2013): 146-148.
Elemo, O.O., Akinyede, A. A., Oreagba, I. A., Nicholas-Okpara, V. A. & Unuofin, J. O. (2022). Uterine Contractile Activity and Abortifacient Effect of the Aqueous Extract of Euphorbia heterophylla L. Leaves in Albino Rats. Pharmacology and Toxicology of Natural Medicines, 2 (1): 1-11. https://doi.org/10.52406/ptnm.v2i1.14
Etim, N. N., Williams, M. E., UduakAkpabio, U. & Offiong, E. E. A. (2014). Haematological Parameters and Factors Affecting Their Values. Agricultural Science, 2 (1): 37-47. https://doi.org/10.12735/as.v2i1p37
Harborne, J. B. (1998). Phytochemical Methods- A Guide to Modern Techniques of Plant Analysis. General Pharmacology, 31(4): 601-606.
Illamola, S., Amaeze, O., Krepkova, L., Birnbaum, A., Karanam, A., Job, K., Bortnikova, V., Sherwin, C. & Enioutina, E. (2020). Use of herbal medicine by pregnant women: What physicians need to know. Frontiers in Pharmacology, 10 (1483): 1-16. https://doi.org/10.3389/fphar.2019.01483
Kone, J. & Onifade, A. (2020). Toxicological effect of Euphorbia heterophylla Linn. Journal of Complementary and Alternative Medical Research, 12 (3): 1-15. https://doi.org/10.9734/jocamr/2020/v12i330207
Mamta, S., Jyoti, S., Rajeev, N., Dharmendra, S. & Abhishek, G. (2013). Journal of Pharmacognosy and Phytochemistry, 1 (6): 168-180.
Mann, A. & Kuta, Y. A. (2014). Antibacterial activity of methanolic extracts of Terminalia avicennioides against fish pathogenic bacteria. American Journal of Research Communication, 2 (4): 133-146.
Mondal, S. & Roy, N. (2022). Pharmacognostic and Phytochemical Evaluation of Leaf of Jatropha nana var. bengalenseC.H. Rahaman and S. Mondal: An Endemic Member of Euphorbiaceae. Pharmacognosy Research, 14 (2): 204-10. https://doi.org/10.5530 /pres.14.2.29
Nalule, A. S., Afayoa, M., Mali, B. & Majidu, M. (2017).Acute oral toxicity of Euphorbia heterophylla Linn. ethanolic extract in albino mice. African Journal of Pharmacy and Pharmacology, 11 (1): 1-9. https://doi.org/10.5897/AJPP2014.4186
Nalule, A. S., Mbaria, J. M. & Kimenju, J. W. (2013). In vitro anthelmintic. Ethnopharmacological practices in management of livestock helminthes by pastoral communities in the drylands of Uganda. Livestock Res. Rural Dev. 23 p.
Oso, B. A. & Ogunnusi, T. A. (2017). Antibacterial Activity of Methanolic Extracts of Euphorbia heterophylla and Tithonia diversifolia against Some Microorganisms. European Journal of Medicinal Plants, 20 (3): 1-8. https://doi.org/10.9734 /EJMP/2017/28568
Olaniyan, L. W. B., Maduagwu, E. N., Akintunde, O. W., Oluwayelu, O. O. & Brai, B. I. C., 2015. Lamivudine-Induced Liver Injury. Macedonian Journal of Medical Sciences, 3 (4): 545-550. https://doi.org/10.3889/oamjms.2015.110
Oloninefa, S. D., Abalaka, M. E., Daniyan, S. Y. & Mann, A. (2018). Phytochemical Screening and Antibacterial Susceptibility of Whole Plant of Euphorbia Heterophylla Crude Extracts against Selected Bacteria Pathogens. Bayero Journal of Pure and Applied Sciences, 11 (1): 211-220. https://doi.org/10.4314/bajopas.v11i1.37
Oyedum, U. M. (2022). Comparative study of the phytochemical and antibacterial activity of leaf extracts of Euphorbia heterophylla and Vitellaria paradoxa. African Journal of Microbiology Research, 16 (5): 202-210. https://doi.org/10.5897/AJMR2021.9612
Saganuwan, S. A. (2017). Toxicity studies of drugs and chemicals in animals: An overview. Bulgarian Journal of Veterinary Medicine, 20 (4): 291-318. https://doi.org/10.15547/bjvm.983
Trease, G.E. & Evans, W.C. (1989). Pharmacognosy (13th edition). English Language Book Society (pp. 378,386-480). London, Britain: Bailli`ere Tindall.
Wadankar, G. D., Mahale, B. R., Kute, M. V. & Khadse, P. D. (2022). Investigation of Phytochemical in Euphorbia heterophylla and Euphorbia rothiana. International Journal of Medical, Pharmacy and Drug Research, 6 (3): 16-19. https://doi.org/10.22161/ijmpd.6.3.2
Wellington, E., Peters, D. & Onyeike, E. (2020b). Laxative potential of aqueous extract of the aerial parts of Euphorbia heterophylla in loperamide-induced constipated Wistar albino rats. International Journal of Advanced Research and Publications, 4 (1): 111- 117.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 UMYU Journal of Microbiology Research (UJMR)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.