Malaria and Typhoid Fever Coinfection among Febrile Patients Attending Kafin-Maiyaki Primary Health Centre
DOI:
https://doi.org/10.47430/ujmr.2493.027Keywords:
Coinfection, Malaria, Plasmodium species, Salmonella species, Typhoid feverAbstract
Study’s Novelty/Excerpt
- This study investigates the burden and co-existence of malaria and typhoid fever among febrile patients, providing a rare examination of these symptomatically similar but aetiologically distinct diseases in a single patient cohort.
- The novelty of the research lies in its detailed analysis of co-infection rates across different age groups and genders, highlighting significant age-related disparities and suggesting the higher vulnerability of older patients.
- These findings underscore the importance of concurrent screening for malaria and typhoid fever in febrile patients, offering critical insights for improving diagnostic and treatment strategies in the study area.
Full Abstract
Malaria and typhoid fever are two symptomatically similar but aetiologically dissimilar diseases: mala ria is caused by parasitic agents from Plasmodium species; ty phoid fever, on the other hand, is caused by Salmonella typhi. They both have no gender distinction in terms of their effect, but malaria appears to be more severe among children. The study aimed to determine the burden of these two diseases among febrile patients in the study area by collecting four (4) mL of blood from each participant, 2 mL of which were dispensed into EDTA bottles for use to detect microscopic parasites. The harvested serum from the remainder was used for the Widal agglutination test to detect the presence of antibodies to Salmonella species. Based on the results, malaria and typhoid fever co-existence was found to be 20.9%. The findings with respect to age group revealed that patients >60 years had a higher coinfection rate of 75% while the 1-12 years age group had the least coinfection (10.6%). There was a significant association between coinfection and age groups (p = 0.019). With respect to gender, females were more prone to be co-infected (53.6%) compared to their male counterparts (46.4%) out of the total positive cases (28) obtained, but the observed difference was not statistically significant (p = 0.016). We therefore recommend concurrent screening of these diseases in all febrile cases in the study area.
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References
Anand, N., & Anand, N. (2018). Incidence of coinfection of malaria and typhoid and their diagnostic dilemmas. RAPL, 4(4), 10-12. https://doi.org/10.24321/2454.8642.201815
Antonio-Nkondjio, C., Cyrille, N. & Flobert, N. (2019). “Review of malaria situation in Cameroon: technical viewpoint on challenges and prospects for disease elimination. Parasites and Vectors, 12(1), 501–523. https://doi.org/10.1186/s13071-019-3753-8
Birhanie, M., Tessema B., Ferede G., Endris M., & Enawgaw, B. (2014). Malaria, typhoid fever, and their coinfection among febrile patients at a rural health center in Northwest Ethiopia: a cross-sectional study. Advances in medicine, 8, 2014. https://doi.org/10.1155/2014/531074
Buckle, G. C., Walker, C. L. & Black, R. E. (2012). “Typhoid fever and paratyphoid fever: systematic review to estimate global morbidity and mortality for 2010. Journal of Global Health, 2, 1. https://doi.org/10.7189/jogh.01.010401
Chilongola, J. Kombe, S. & Horumpende, P. (2018). “Prevalence of Plasmodium falciparum and Salmonella typhi infection and coinfection and their association with fever in Northern Tanzania. East African Health Research Commission, 2(2), 147-155. https://doi.org/10.24248/eahrj.v2i2.589
Cochran, W. G. (1963). Sampling techniques, (3rd edition).Wiley. New York. John Wiley and Sons, Inc. p.75, 124-125.
Dinah K., Tonny A., & Moses, O. (2016). Prevalence of Plasmodium and salmonella coinfection among febrile patients attending outpatient department of Lira Regional Referral Hospital in Northern Uganda: a cross-sectional study. Journal of Disease and Global Health, 7(4), 183-187.
Ekesiobi, A. O., Igbodika, M. C. & Njoku, O. O. (2008). Coinfection of malaria and typhoid fever in a tropical community; Animal Research International, 5(3), 888-891. https://doi.org/10.4314/ari.v5i3.48754
Igiri, B. E., Ejezie, G. C., Inyang-Etoh, P. C., Jimoh, O., & Okoduwa, S. I. R. Otu-Bassey, I. B. & Ogba, O. M. (2018). Incidence of malaria and salmonellosis coinfection in Ahmadu Bello University Teaching Hospital, Zaria, North-West Nigeria. ClinSci Res Rep, 1(2), 1-5. https://doi.org/10.15761/CSRR.1000109
Iwuafor, A. A., Egwuatu, C. C., Nnachi, A. U., Akujobi, C. N., & Ita, I. O. (2016). Malaria-related febrile illness and the use of Insecticide-Treated Nets (INTs) for malaria control amongst under-5 year old children in Calabar, Nigeria. BMC Infect Dis, 16, 151-160. https://doi.org/10.1186/s12879-016-1459-5
Kaboré, B., Post, A., & Lompo, P. (2021). Aetiology of acute febrile illness in children in a high malaria transmission area in West Africa. Clinical Microbiology and Infections, 27(4), 590-596. https://doi.org/10.1016/j.cmi.2020.05.029
Mohammed, H. I., Mukhtar, I. M. & Sadiq, H. A. (2020). Malaria and typhoid fever: prevalence, coinfection and socio-demographic determinants among pregnant women attending antenatal care at a primary healthcare facility in Central Nigeria. International Journal of Pathogen Research, 5(4), 17–24. https://doi.org/10.9734/ijpr/2020/v5i430140
Odikamnoro, O.O., Ikeh, I. M., Okoh, F. N., Ebiriekwe, S. C., Nnadozie, I. A., Nkwuda, J. O. & Asobie, G. C. (2018). Incidence of malaria/typhoid coinfection among adult population inunwana community, afikpo north local government area, ebonyistate, southeastern nigeria. Afr J Infect Dis, 12(1), 33-38.
Okore, O. O., Ubiaru, P. C., & Nwaogwugwu, U. G. (2015). Prevalence of Malaria and Typhoid Fever Coinfection: Knowledge, Attitude and Management Practices among Residents of Obuda-Aba, Abia State, Nigeria. American Journal of Public Health Research, 3(4), 162-166
Sale, M. Pukuma, M. Adedeji, B. & Shehu, A. (2020). “Prevalence of typhoid and malaria coinfection among patients attending a public hospital in Yola, Nigeria,” International Journal of Mosquito Research, 7(3), 42-47.
Sangaré, I. S. Yacouba, B. Wifried, W. S. Constant, D. F., Sanou, S. Z. Jacques, P. A. Ouédraogo, A. S. & Bamba, S. (2021). Institut Supérieur des Sciences de la Santé, Université Nazi BONI, Bobo-Dioulasso, Burkina Faso (2021). Malaria and Typhoid Fever Coinfection in the Hospital University of Bobo-Dioulasso, Burkina Faso. Journal of Parasite Research, 1(1), 21-25
Simon-Oke L. A. & Akinbote, M. O. (2020). Prevalence of Malaria and Typhoid Coinfection in Relation to Haematological Profile of University Students in Akure, Nigeria. Journal of Infectious Diseases and Epidemiology, 6(5), 166. https://doi.org/10.23937/2474-3658/1510166
Ubengama, N. Useh, M. & Ben, S. (2019). “High occurrence of typhoid fever and malaria coinfection among patients clinically diagnosed of malaria and or typhoid infection in Calabar, Nigeria,” Journal of Medical Laboratory Science, 29(2), 1-9
Wasihun, A. G., Wlekidan, L. N., Gebremariam, S. A., Welderufael, A. L., Muthupandian, S., & Haile, T. D., (2015). Diagnosis and treatment of typhoid fever and associated prevailing drug resistance in northernEthiopia. Int J Infect Dis, 35, 96–102. https://doi.org/10.1016/j.ijid.2015.04.014
World Health Organization, (2016). World Malaria Report, Geneva, World Heal the Organ.
Zerfu B., Medhin G., Mamo G., Getahun G., Tschopp R., & Legesse, M. (2018). Community-based prevalence of typhoid fever, typhus, brucellosis and malaria among symptomatic individuals in Afar Region, Ethiopia. PLoS Neglected Tropical Diseases; 12(10), e0006749. https://doi.org/10.1371/journal.pntd.0006749
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