Prevalence of Human Papilloma Virus among women of child bearing Age in Yola Adamawa State, Nigeria

Authors

  • Nafisat Adamu Kachalla Department of Microbiology, School of life sciences, Modibbo Adama University of Technology Yola. Adamawa State, Nigeria.
  • Halima Isa Department of Microbiology, School of life sciences, Modibbo Adama University of Technology Yola. Adamawa State, Nigeria.
  • Mohammed Bashir Department of Microbiology, School of life sciences, Modibbo Adama University of Technology Yola. Adamawa State, Nigeria.
  • Shinjawa Yunana Heamotology Department, Specialist Hospital Yola. Adamawa State Nigeria

DOI:

https://doi.org/10.47430/ujmr.2162.004

Keywords:

Cervical-cancer, Human papilloma virus, High vaginal swab,, high risk,, sexually transmitted,, APTIMA assay.

Abstract

Epidemiological, molecular and clinical evidences have shown that cervical cancer is caused by the human papilloma-virus HPV), especially genotype 16 18 and 45. This study aims to survey the prevalence of high-risk types of HPV 16 18/45 among women of child-bearing age. Three hundred 300) women aged 18 years and above were randomly selected from the community and patients attending Specialist Hospital Yola (S.H.Y) and Federal Medical Center (F.M.C) Yola, Adamawa State. Relevant sexual and socio-demographic information was obtained from each subject using a questionnaire. High Vaginal swab samples were collected and analyzed using APTIMA Assay to identify the high-risk HPV genotype 16, 18 and 45. Out of the 300 samples analyzed, 56 (18.7%) were positive, 238 (79.3%) were negative for HPV and 6 (2%) are invalid. Out of the positive samples obtained, 29 (51%) were HPV 16 while 27 (48.2%) were HPV 18/45. The study also showed that the age grade of 24-41 years had the highest prevalence of 25.6 %. No positive sample was found among age grades of 18-23. The result shows that HPV prevalence was significantly associated with the number of sexual partners (P=0.009).

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References

Cohen, J. (2005) public health HPVs peculiarities from infection to disease. Science Journal Vol. 29: 308- 319

https://doi.org/10.1126/science.308.5722.619

Center for Disease Control (CDC, 2006): Sexually Transmitted disease treatment guideline available online from https www.cdc.gov

Hildshein A., M. H. Schiffman, P. E Gravitt., A.G. Glass, C.E. Greer, T. Zhang, D. R. Scott, B.B. Rush, P. Lawler, M. E. Sherman (1994): Persistence of type specific human papillomavirus infection among cytologically normal women.Journal of Infectious Diseases 169:235-240

https://doi.org/10.1093/infdis/169.2.235

Monsonego J., F.X. Bosch, P. Coursaget, J. T. Cox, E. Franco, I. Frazer, T. C. Wright, R. Sankaranarayanan, J. Schiller, A. Singer, W. Jr. Kinney, C. J.S. Meije, J. Linder, D.M Parkin, J. Ferlay, M. Hamdi-Cherif, F. Sitas, J.O.Thomas, H. Wabbinga, S.I. Whelan (2003): Cancer in Africa Epidemiology and Prevention of cervix cancer. IARC Scientific Publication No 153, LYON:IARC Press pp268-276

Safaein M., M. Schiffman, J. Gage, D. Solomon, C. Wheeler, P. Castle (2009): Detection of precancerous cervical lesion is differentiated by Human Papillomavirus type. Cancer Research. 69 (8):3262-3266

https://doi.org/10.1158/0008-5472.CAN-08-4192

Walboomer J.M, M.V. Jacobs, M.M. Manos, F.X. Bosch, J. A. Kummer, K. V. Shah, J. Snijder, J. Peto, C. J. Meije, N. Munoz (1999): Human papillomavirus is a necessary cause of invasive cervical cancer Worldwide. Journal of Pathology.Vol. 189:12-19

https://doi.org/10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F

Thomas J.O., R. Herrero, A.A. Omigbodun, K. Ojemakinde, I.O. Ajayi, A. Fawole (2004): Prevalence of papillomavirus infection in women in Ibadan Nigeria: A population-based study. British Journal of Cancer Vol.90 (3): 638-645

https://doi.org/10.1038/sj.bjc.6601515

Map of Adamawa State Available online from www.adamawastate.com

Naing L., T. Winn, B.N. Rushi (2006): Practical issue in calculating the sample size for prevalence studies. Journal Archieve of Orofacial science Vol.1: 9-14

APTIMA® HPV 16 18/45 Genotype Assay. https://www.accessdata.fda.gov/cdrh_docs/pdf12/P120007c.

Didelot-Rousseau M.N., N. Nagot, V. Costes-Maritineau, X. Valles, A. Ouedraogo, I. Konate (2006): Human papilloma virus genotype distribution and cervical squamous intraepithelial lesions among high risk women with and without HIV-1 infection in Burkina Faso. British Journal of Cancer; Vol. 95 (3):355-62

https://doi.org/10.1038/sj.bjc.6603252

Serwadda D., M. J. Wawer, K.V. Shah, N.K. Sewankambo, R. Daniel, C. Li, A. Lorincz, M.P. Meehan, F. Wabwire-Mangen, R.. H. Gray. (1999) Use of a hybrid capture assay of self-collected vaginal swabs in rural Uganda for detection of human papillomavirus. Journal of Infectious Diseases. 180:1316-1319

https://doi.org/10.1086/315026

Womack S.D., Z.M. Chirenje, L. Gaffikin P.D. Blumenthal, J. A. McGrath, T. Chipato, S. Ngwalle, M. Munjoma, K.V. Shah (2000): HPV-based cervical cancer screening in a population at high risk for HIV infection. International Journal Cancer; Vol. 85:206-210

https://doi.org/10.1002/(SICI)1097-0215(20000115)85:2<206::AID-IJC10>3.0.CO;2-Q

https://doi.org/10.1002/(SICI)1097-0215(20000115)85:2<206::AID-IJC10>3.3.CO;2-H

Xi L.F.and Toure P. (2006): HPV genotype distribution and squamous intraepithelial lesions among high-risk women with and without HIV-1infection in Burkina faso. British Journal for Cancer Vol. 95:355-362

https://doi.org/10.1038/sj.bjc.6603252

Clifford G. M., Smith J.S, M. Plummer, N. Muñoz, S. Franceschi (2003). Human Papilloma virus types in invasive cervical cancer worldwide: a meta-analysis. British Journal for Cancer; Vol. 88:63-73.

https://doi.org/10.1038/sj.bjc.6600688

Jacobs V. M., J. M. Walboomers, P. J. Snijders, F. J. Voorhorst, R. H. Verheijen, N. Fransen-Daalmeijer, C.J Meijer (2000). Distribution of 37 mucosotropic HPV types in women with cytologically normal cervical smears: the age-related patterns for high-risk and low-risk types. International Journal for Cancer. Vol.87:221-227

https://doi.org/10.1002/1097-0215(20000715)87:2<221::AID-IJC11>3.0.CO;2-2

Kjaer S.K., B. Chackerian, A.J.C. van der Brule, E.I. Svare, l.G. Paul, J.M.M. Walboomers, J. T. Schiller, J. E. Bock, M.E., Sherman, D.R Lowy, C.J.L.M., Meijer (2001). High-Risk Human Papilloma Virus Is Sexually Transmitted: Evidence from a Follow-up Study ofVirgins Starting Sexual Activity Intercourse) Cancer Epidemiology Biomark Prevention, Vol.10:101-105

Anh P.T.H, N.T. Hieu, R.. Herrero (2003). Human papillomavirus infection among women in South and North Vietnam. International Journal of cancer.Vol.104:213-220

https://doi.org/10.1002/ijc.10936

De Sanjose S., R. Almirall, B. Lloverus, R. Front, M. Diaz, N. Murioz, I. Catala, C. J. Meijer, P. j. Snijders, R.. Herrero, F. X. Bosch (2003). Cervical human Papilloma virus Infection in the Female Population in Barcelona, Spain. Sexually Transmitted Diseases. Vol.30: 788 - 793

https://doi.org/10.1097/01.OLQ.0000080177.82204.E0

Castellsague X., C. Menendez, M. P. Loscertales, J. R. Kornegay, F. dos Santos, F.X., Gomez-Olive, B., L. Loveras, N., Abarca, N Vaz., A Barreto.., F.X Bosch,., P Alonso (2001). Human papillomavirus genotypes in rural Mozambique. Lancet; Vol.358:1429-1430

https://doi.org/10.1016/S0140-6736(01)06523-0

De Vuyst H., S. Steyaert, L. Van Renterghem, P. Claeys, L. Muchiri, S. Sitati, S. Vansteelandt, W. Quint, B. Kleter, E. Van Marck, M. Temmerman (2003). Distribution of human Papilloma virus in a family planning population in Nairobi, Kenya. Sexually Transmitted Diseases. Vol.30:137-142

https://doi.org/10.1097/00007435-200302000-00009

Nweke I.G., A. A. F. Banjo, F. B. Abdulkareem, V.U. Nwadike (2013). Prevalence of Human Papilloma Virus DNA in HIV Positive Women in Lagos University Teaching Hospital LUTH) Lagos, Nigeria. British Microbiology Research Journal. Vol.3 (3): 400-413

https://doi.org/10.9734/BMRJ/2013/4151

Singh, K. Anastos, D. R. Hoover, R. D. Burk, Q. Shi, L. Ngendahayo (2009). Human papilloma virus infection and cervical cytology in HIV infected and HIV uninfected Rwandan women. Journal of Infectious Diseases Vol.199 (12):1851-61

https://doi.org/10.1086/599123

World Health Organization (2006): Cervical cancer, Human Papilloma virus and HPV cervical. WHO/RHR/08.14

Bosch F.X., Y. L. Qiao, X. Castellsague (2006). The epidemiology of human Papilloma virus infection and its screening. International journal of gynecology and obstetrics. Vol.94: 1-8

https://doi.org/10.1016/S0020-7292(07)60004-6

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Published

30-12-2021

How to Cite

Nafisat Adamu Kachalla, Halima Isa, Mohammed Bashir, & Shinjawa Yunana. (2021). Prevalence of Human Papilloma Virus among women of child bearing Age in Yola Adamawa State, Nigeria. UMYU Journal of Microbiology Research (UJMR), 6(2), 24–29. https://doi.org/10.47430/ujmr.2162.004