Antibiotic resistance and heavy metal tolerance of livestock-associated Methicillin resistant Staphylococcus aureus in selected livestock settings in Zaria, Nigeria
DOI:
https://doi.org/10.47430/ujmr.2492.023Keywords:
Anti-microbial resistance, livestock, Abattoir, MRSA, heavy metal tolerance, poultry farmAbstract
Study’s Excerpt:
• Most S. aureus isolates had a MAR index ≥0.2 and exhibited beta-lactam resistance.
• S. aureus isolates exhibited varying copper and zinc tolerance irrespective of their source.
• There was a correlation between MAR index and copper tolerance limit of S. aureus isolated from poultry farms.
• The total MRSA from the abattoir and cattle ranch was greater than that from poultry farms.
• However, the MRSA of poultry farm workers was greater than that of abattoir/cattle ranch workers.
Full Abstract:
The inappropriate antibiotic use in animal husbandry raises concerns about possible reservoirs and transmission pathways of methicillin-resistant Staphylococcus aureus (MRSA) in livestock environments. This study assessed the antibiotic resistance and heavy metal tolerance of S. aureus isolated from livestock farm settings; abattoir and cattle ranch, and poultry farms in Zaria, Nigeria. This involved sample and data collection, heavy metal analysis, isolation of S. aureus, antibiogram, and heavy metal tolerance assay. Copper and Zinc concentrations varied in the water and animal wastes (cow dung and poultry litter) samples. Copper concentrations were higher in the cow dung (13.5-16.0 mg/L) compared to poultry litter (7.8-12.2mg/L). Zinc concentrations were higher in poultry litter (77.7-99.9 mg/L) compared to cow dung (44.1-66.4 mg/L). Out of a total of 76 S. aureus isolates, 65.8% (50/76) were MRSA with 77.8% (28/36) and 55% (22/40) from the abattoir and cattle ranch, and poultry farms respectively. S. aureus with MAR index ≥0.2 were greater for the abattoir and cattle ranch (75%) compared with those from the poultry farms (50%) with most isolates exhibiting beta-lactam resistance. MRSA distribution varied with sample type with most isolated from water samples. MRSA isolates from livestock handlers in the poultry farms (27.3%) were greater than those from the abattoir and cattle ranch (7.1%). S. aureus isolates exhibited varying Copper and Zinc tolerance limits irrespective of their source. Proper implementation of biosecurity measures, antimicrobial resistance (AMR) surveillance, and policies are required to decrease the transmission of MRSA and AMR dissemination in livestock settings.
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Copyright (c) 2024 Sadiqa Muktar Ibrahim , Halima Hamisu Ibrahim , Abubakar Baba Abubakar , Badamasi Yahya, Abubakar Muhammad, Jabeer Mahmud, Khadijah Salisu Muhammad ; Seniyat Larai Afegbua
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