Comparative Study and Analysis of Clotting Profiles Between Covid-19 And Non-Covid-19 Patients In Barau Dikko Teaching Hospital, Kaduna

Abdulfatai K; Abdullahi B; Jaafaru IA; Ezeh JN; Haruna DS; Achi, MF

doi:10.47430/ujmr.2162.016

Authors

Abdulfatai K Department of Microbiology, Kaduna State University, Kaduna, Nigeria
Abdullahi B Department of Microbiology, Ahmadu Bello University, Zaria, Nigeria
Jaafaru IA Department of Microbiology, Kaduna State University, Kaduna, Nigeria
Ezeh JN Department of Microbiology, Kaduna State University, Kaduna, Nigeria
Haruna DS Department of Medical Laboratory Sciences, Kaduna State University, Nigeria
Achi, MF Department of Medical Laboratory Sciences, Kaduna State University, Nigeria

DOI:

https://doi.org/10.47430/ujmr.2162.016

Keywords:

Coronavirus,, Prothrombin,, Patients,, Thromboplastin

Abstract

Coronavirus disease 2019 (COVID-19) is associated with coagulation abnormalities- disordered hemostasis and high thrombotic risk. The aim of the study was to compare and analyze the clotting profiles between COVID-19 and non-COVID-19 patients in Barau Dikko Teaching Hospital, Kaduna. Conventional coagulation tests such as Activated Partial Thromboplastin Time (APTT), Prothrombin time (PT) and International normalized ratio (INR) were used to determine the coagulation in the respondents. Fifty (50) samples were collected for the test. Out of these samples collected, twenty five 25 were positive for COVID-19. Age group 61-70 had the highest percentage of positive cases 40% while age group 41-50 had the least percentage of positive cases 4% respectively. Concerning gender, males had the higher number of positive cases 15 than their female counterparts 10. All epidemiological and clinical data were collected; analyzed and comparative results were carried out. The presence of history of previous diseases was more among COVID-19 patients than non-COVID-19 patients. The clinical characteristics between COVID-19 and non COVID-19 patients showed similarities in body temperature, catarrh, headache, sore throat and sputum, but the presence of heavy cough was observed among COVID-19 patients. The clinical laboratory results showed significant difference (p<0.05) and positive correlation were found among the PT (0.17), APTT (0.12) and INR (0.08) between COVID-19 and non COVID-19 patients. These results are indications that there is need for more research in this area of study to know the clinical manifestation of COVID-19 virus among patients.

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References

Annunziata, A., Imitazione, P. and Polistina, G. E. (2020).Pulmonary embolism in Covid-19.coagulation parameters, close monitoring to prevent? Turkish Thoracic Journal, 21:287-288.

https://doi.org/10.5152/TurkThoracJ.2020.20067

Assiri, A., Al-Tawfiq, J.A., Al-Rabeeah, A.A., Al-Rabiah, F.A., Al-Hajjar, S., Al-Barrak, A., et al. (2013). Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infectious Disease.13:752-61.

https://doi.org/10.1016/S1473-3099(13)70204-4

Bikdeli, B., Madhavan, M. V., Jimenez, D., Chuich, T., Dreyfus, I. and Driggin, E. (2020).COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up. Journal of the American College of Cardiology, 75(23):2950-2973

https://doi.org/10.1016/j.jacc.2020.04.031

CNNBusiness.(2020.).https://edition.cnn.com/2020/01/31/economy/chinaeconomy-coronavirus/index.html.

Favaloro, E. J. and Thachil, J. (2020).Reporting of D-dimer data in COVID-19: some confusion and potential for misinformation. Clinical Chemistry and Laboratory Medicine, 58(8):1191-1199.

https://doi.org/10.1515/cclm-2020-0573

Giannis, D., Ziogas, I. A. and Gianni, P. (2020).Coagulation disorders in coronavirus infected patients:COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past. Journal of Clinical Virology;127: 104362.

https://doi.org/10.1016/j.jcv.2020.104362

Hampton,, T. (2021). Auto-antibodies may drive COVID-19 Blood Clots. American Medical Association,325 (5). 425.

https://doi.org/10.1001/jama.2020.25699

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J. and Hu, Y. (2020).Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet.395(10223):497-506.

https://doi.org/10.1016/S0140-6736(20)30183-5

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J. Hu y, et al. (2020).clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497-506.

https://doi.org/10.1016/S0140-6736(20)30183-5

Jamaatia, H., Dastana, F., Tabarsic, P., Marjanic, M., Saffaeid. A. and Hashemiana, M. R. (2020). A fourteen-day experience with Coronavirus Disease 2019 (COVID-19) induced acute respiratory distress syndrome (ARDS): an Iranian treatment protocol. Iranian Journal of Pharmaceutical Research, 19 (1):31-36.

Killerby M.E., Biggs, H.M., Midgley, C.M., Gerber, S.I., Watson, J.T. (2020).Middle East respiratory syndrome coronavirus transmission. Emerging Infectious Disease.26:191-8.

https://doi.org/10.3201/eid2602.190697

Li, G., Fan, Y., Lai, Y., Han, T., Li, Z., Zhou, P., Pan, P., Wang, W., Hu, D., Liu, X., Zhang, Q., Wu, J. (2020).Coronavirus infections and immune responses. Journal of Medical Virology, 92:424-432.

https://doi.org/10.1128/IAI.00246-20

https://doi.org/10.1128/IAI.00759-19

https://doi.org/10.1128/IAI.00035-20

https://doi.org/10.1128/IAI.00288-20

https://doi.org/10.1128/IAI.00754-19

https://doi.org/10.1128/IAI.00875-19

Llitjos, J. F., Leclerc, M., Chochois, C., Monsallier, J. M., Ramakers, M. and Auvray, M. (2020).High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients. Journal of Thrombosis and Haemostasis, 18(7): 1743-6.

https://doi.org/10.1111/jth.14869

Lodigiani, C., Iapichino, G., Carenzo, L., Cecconi, M., Ferrazzi, P. and Sebastian, T. (2020).HumanitasCOVID-19 Task Force. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospitalin Milan, Italy. Thrombosis Research, 191: 9-14.

https://doi.org/10.1016/j.thromres.2020.04.024

McGonagle, D., O'Donnell, J. S., Sharif, K., Emery, P. andBridgewood, C. (2020).Immune mechanisms ofpulmonary intravascular coagulopathy in COVID-19 pneumonia. Lancet Rheumatology, 2(7):e437-45.

https://doi.org/10.1016/S2665-9913(20)30121-1

NCDC.(2020). First case of corona virus disease confirmed in Nigeria.Retrieved on 16th March, 2021.

Obi, A. T., Tignanelli, C. J., Jacobs, B. N., Arya,S.,Park, P. K. and Wakefield, T. W. (2019). Empirical systemic anticoagulation is associated with decreased venous thromboembolism in critically ill influenza A H1N1 acute respiratory distresssyndrome patients. Journal of Vascular Surgery: Venous and Lymphatic Disorders,7(3): 317-24.

https://doi.org/10.1016/j.jvsv.2018.08.010

Pavoni, V., Gianesello, L., Pazzi, M., Stera, C., Meconi, T. and Frigieri, F. C. (2020).Evaluation of coagulation function by rotation thromboelastometry in critically ill patients with severe COVID-19 pneumonia. Journal of Thrombosis and Thrombolysis, 50(2), 281-286.

https://doi.org/10.1007/s11239-020-02130-7

Sayad, B. and Rahimi, Z. (2020). Blood coagulation parameters in patients with SevereCOVID-19 from Kermanshah Province, Islamic Republic of Iran.Eastern Mediterranean Health Journal, 26 (9):999-1004.

https://doi.org/10.26719/emhj.20.105

Tang, N., Li, D., Wang, X. and Sun, Z. (2020). Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. Journal of Thrombosis and Haemostasis, 18(4):844-7.

https://doi.org/10.1111/jth.14768

Wool, G. D. and Miller, J. L. (2021).The Impact of COVID-19 Disease on Platelets and Coagulation.Pathobiology;88:15-27.

https://doi.org/10.1159/000512007