Antibacterial Efficacy of Locally Prepared Erectile Dysfunction Concoctions on Escherichia Colica using Urinary Tract Infection
DOI:
https://doi.org/10.47430/ujmr.25103.003Keywords:
Urinary tract infections, Erectile dysfunction, Traditional medicine, Antibacterial activity, PhytochemicalsAbstract
Study’s Excerpt:
- ED herbal concoctions showed up to 26 mm inhibition zones against UTI-causing E. coli.
- GC–MS revealed both plant-derived and synthetic compounds in traditional ED remedies.
- Some concoctions contained bipyridine and triazine—synthetic agents not found in sildenafil.
- Antibacterial efficacy supports potential UTI management, but safety remains unverified.
- Findings highlight the need for further pharmacological and toxicological evaluations.
Full Abstract:
Urinary tract infections (UTIs) are a major global health concern among men and are often associated with complications that may lead to erectile dysfunction (ED), which in turn can cause low self-esteem, depression, anxiety, and a range of psychological challenges. Conventional treatments for UTIs and ED typically involve synthetic drugs that can produce significant side effects, thereby driving interest in traditional medicinal alternatives. In this study, we randomly selected locally prepared ED concoctions and evaluated their antibacterial efficacy against selected Escherichia coli isolates from male UTI patients. The isolation and antibacterial activity of the E. coli isolates were carried out using standard phenotypical and microbiological techniques. Additionally, qualitative phytochemical screening and GC–MS analysis were employed to profile the bioactive compounds present in the concoctions. The antibacterial activity was assessed by measuring zones of inhibition, with some samples exhibiting zones up to 26 mm, indicating promising activity. Our results further revealed a complex chemical composition that included both natural compounds, such as fatty acids with documented antibacterial properties, and synthetic agents, including bipyridine and triazine derivatives, which are not typically found in conventional ED medications like sildenafil citrate. These findings suggest that while the traditional ED concoctions are primarily derived from plant sources, they are not entirely natural; synthetic compounds appear to be incorporated, possibly to enhance efficacy. Overall, our study underscores the need for further quantitative and toxicological analyses to establish the pharmacological basis and safety profile of these alternative remedies.
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