Resistance Patterns of Mycobacterium tuberculosis to First-Line Anti-TB Drugs in Kaduna State, North-Western Nigeria
DOI:
https://doi.org/10.47430/ujmr.2051.011Keywords:
Resistance, Mycobacterium tuberculosis, first-line anti-TB drugs, Kaduna, North- western NigeriaAbstract
The problem of tuberculosis (TB) in Nigeria has been made worse by the issues of drug resistant Mycobacterium tuberculosis. Resistance associated with treatment failures has become a common occurrence worldwide. Of particular concern is the increasing prevalence of multi drug resistant M. tuberculosis; organisms resistant to isoniazid and rifampicin, the two drugs that form the backbone of modern short-course therapy. Susceptibility of forty (40) M. tuberculosis isolates to isoniazid (INH), rifampicin (RIF), streptomycin (SM) and ethambutol (EMB) was determined by the proportion method on Lowenstein Jensen egg based slopes containing critical concentrations of INH, RIF, SM and EMB (0.2 μg/ml, 40 μg/ml, 4.0 μg/ml and 2.0 μg/ml respectively). Overall drug resistance was found in 21 (52.5%) isolates. Mono-drug resistance was seen in 9 (22.5%) of the isolates tested and was against streptomycin. Two (5.0%) isolates were found to be MDR. Five (12.5%) were poly-drug resistant. One isolate showed poly-drug resistance to SM and INH, 2 (5%) were poly-drug resistant to SM and EMB, 1 (2.5%) was resistant to INH and EMB. Poly resistance to SM, INH and EMB was found in only 1 isolate. No poly-resistance to RIF and EMB, RIF and SM or RIF/SM/EMB was observed.
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References
Canetti, G., Froman, S., Grosset, J., Hauduroy, P., Langerova, M., Mahler, H.T., Meissner, G., Mitchison, D.A., and Sula,L. (1963). Mycobacteria: Laboratory methods for testing drug sensitivity and resistance. Bulletin of the World Health Organization, 29:565-578.
Canetti, G., Fox, W., Khomenko, A., Mahler, H.T., Menon, N.K., Mitchison, D.A.,Rist, N., Smelev, N.A. (1969). Advances in techniques of testing mycobacterial drug sensitivity, and the use of sensitivity tests in tuberculosis control program. Bulletin of World Health Organization, 41(1):21-43.
Dye, C., Williams, B.G., Espinal, M.A., and Raviglione, M.C. (2002)."Erasing the world's slow stain: strategies to beat multi drug resistant tuberculosis," Science, 295(5562): 2042-2046.
https://doi.org/10.1126/science.1063814
Hassan, S.O., Musa, M.T., Elsheikh, H.M., Eleragi, A.M.S. and Saeed, N.S. (2012). Drug Resistance in Mycobacterium tuberculosis isolates from Northeastern Sudan. British Journal of Medicine and Medical Research, 2(3): 424-433.
https://doi.org/10.9734/BJMMR/2012/1404
Joint Tuberculosis Committee of the British Thoracic Society (1998). Chemotherapy and management of tuberculosis in the United Kingdom: recommendations. Thorax; 53, 536-548.
https://doi.org/10.1136/thx.53.7.536
Leimane, V. and Leimans J. (2006). Tuberculosis control in Latvia: integrated DOTS and DOTS-Plus programmes. Eurosurveillance;11:1-3.
https://doi.org/10.2807/esm.11.03.00610-en
Meriki, H.D., Tufon, K.A., Atanga, P.N., Ane- Anyangwe, I.N., Anong, D.N., Cho- Ngwa, F. and Nkuo- Akenji, T. (2013). Drug Resistance Profiles of Mycobacterium tuberculosis Complex and Factors Associated with Drug Resistance in the Northwest and Southwest Regions of Cameroon. PLoS ONE,8(10): e77410.
https://doi.org/10.1371/journal.pone.0077410
Mukherjee, J.S., Rich, M.L., Socci, B.A., Joseph, A.R., Virú, K., Shin, F.A.,Furin, S.S., Becerra, J.J., Barry, M.C.,Kim, D.J., Bayona, J.Y., Farmer, J.,Fawzi, P., and Seung, K.J. (2004). Programmes and principles for management of multidrug resistant tuberculosis. Lancet, 372(9407):474-481.
https://doi.org/10.1016/S0140-6736(04)15496-2
National Drug-resistant TB prevalence survey report, Nigeria: National TB Drug resistance survey report (2012). Nigeria.
Onyedum, C. C., Alobu, I. and Ukwaja, K. N. (2017). Prevalence of drug-resistant tuberculosis in Nigeria: A systematic review and meta-analysis. PLoS ONE 12(7): e
https://doi.org/10.1371/journal.pone.0180996
Ormerod, L.P. (1997). Chemotherapy of tuberculosis. European Respiratory Journal, 2:273-297.
Pablos-M'endez, A., Knirsch, C.A., Barr, R.G., Lerner, B.H. and Frieden, T.R. (1997). Nonadherence in tuberculosis treatment: predictors and consequences in New York City. American Journal of Medicine, 102(2):164-170.
https://doi.org/10.1016/S0002-9343(96)00402-0
Sethi, S., Mewara, A., Dhatwalia, S.K., Singh, H., Yadav, R., Singh, K., Gupta, D., Wanchu, A. and Sharma, M. (2013). Prevalence of multidrug resistance in Mycobacterium tuberculosis isolates from HIV seropositive and seronegative patients with pulmonary tuberculosis in north India. Infectious Diseases,13:137.
https://doi.org/10.1186/1471-2334-13-137
Sharma, S.K. and Mohan, A. (2006). Multidrug- resistant tuberculosis: A menace that threatens to destabilize tuberculosis control. Chest, 130(1):261-272.
https://doi.org/10.1016/S0012-3692(15)50981-1
World Health Organization (2013).Global tuberculosis report 2013:http://www.who.int/tb/publicati ons/global_report/en/
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