Seroprevalence of Anti HSV-2 IgG among Women of Reproductive Age attending General Hospital Dutse

Authors

  • Sani, N. M., Department of Microbiology and Biotechnology, Federal University Dutse.
  • Rukayya, H.M., Department of Biological Sciences, Federal University Dutse.
  • Ubandoma, M.S., Department of Microbiology, Afe-Babalola University, Ado Ekiti.
  • Mujahid, N.S. Department of Microbiology, Kano University of Science and Technology, Wudil.
  • Oni, M.A. Department of Medical Microbiology and Parasitology, Bayero University Kano.
  • Isaka, I. Department of Microbiology, Federal University Dutsin-ma.

DOI:

https://doi.org/10.47430/ujmr.1941.001

Keywords:

Herpes simplex virus,, ELISA,, Samples,, Seroprevalence,, STIs,, Dutse.

Abstract

Herpes simplex virus type 2 (HSV-2) remains one of the widespread and chronic sexually transmitted infections (STI) globally with highest disease burden in African females. A study to determine the humoral immune response to HSV-2 was carried out with a view to                                                                                                                     “x- raying” the magnitude of the infection among females of reproductive age in Dutse. A total of 94 clients were recruited for the study and Samples were randomly collected after obtaining their consent. A structured questionnaire was administered to capture demographic information in addition to knowledge, attitude and practices of each respondent. Samples were tested for the presence of IgG antibodies against HSV-2 using enzyme linked immunosorbent assay (ELISA). Results were further subjected to Chi-square test using SPSS version 22.0 where p-values of ≤ 0.05 were considered statistically significant. Out of the 94 samples tested, 29 (30.9%) were positive for anti HSV-2 IgG with high Seroprevalence rates among all age groups. However, age group 15-19 recorded the highest Seroprevalence of 46.2%. Similarly, age groups 20-29, 30-39 and ≥ 40 recorded 28.8%, 26.3% and 33.3% respectively. Chi- square test showed that Seroprevalence of HSV-2 was not significantly associated with age, marital status or level of education. However, it was strongly associated with number of sexual partners (p= 0.048). Higher Seroprevalence was also recorded among women with no educational exposure than those with at least primary or higher level of education. However, Seroprevalence of infection was not statistically associated with level of education p= (0.059). Married women recorded a higher Seroprevalence than the singles. The findings of this research indicates a high Seroprevalence of Herpes Simplex - 2 Virus among women of reproductive age which implies a public health problem to the populace of Dutse and Jigawa state at large making it necessary for the government and other stakeholders to properly curtail the situation through public enlightenment, and implementation of other health policies.

 

Downloads

Download data is not yet available.

References

Brown, Z.A., Benedetti, J.K., Ashley, R., Burchett, S., Selke, S., and Vontver, L.A. (1991). Neonatal herpes Simplex Virus infection in relation to asymptomatic maternal time of labour New English Journal of Medicine 167: 942-946.

https://doi.org/10.1097/00006254-199110000-00011

Dada, A.J., Ajayi, A.O., and Diamondstone, L. (1998). A sero-survey of Haemophilis ducreyi, Syphilis, and herpes Simplex Virus type-2 and their association with HIV among sex workers in Lagos, Nigeria. Journal of sexually transmitted diseases 25: 237-42.

https://doi.org/10.1097/00007435-199805000-00004

Diawara, S., Kane, C.T., Legoff, J., Gaye, A.G., and Mboup, S. (2008). Low seroseroprevalence of Herpes simplex virus type 2 among pregnant women in Senegal International Journal of sexual transmitted diseases and acquired immune deficiency syndromes. 19 (3): 159-160.

https://doi.org/10.1258/ijsa.2007.007139

Federal Government of Nigeria (2007): Legal Notice on Publication of the 2006 Census Report. Federal Government of Nigeria official Gazette 4(94):1-8.

Hayatudeen ,M.R., Mukhtar G.L. and Aminu M. (2017). Seroprevalence of Immunoglobulin G Associated with Herpes Simplex Virus Type 2 among Apparently Healthy Individuals in Katsina State, Nigeria. UMYU Journal of Microbiology Research, 2(1):186- 191.

Hayatudeen, M.R., Bashir, A. and Aminu, M. (2018). Seroprevalence of Herpes Simplex Virus Type 2 Among Patients presenting with fever in Katsina State, Nigeria. Bayero Journal of Medical Laboratory Science, 3(1):1-9.

Kroon, S. (1994) Limiting the continued spread of genital herpes. Recommendations from IHMF Management Strategies. Workshop PPs Europe.

Lagarde, B., Auvert, B., and Chege, 5. (2001). Condom use and its association with HIV/STDs in four urban communities in sub- Saharan Africa. Journal of acquired immune deficiency syndromes 15: 571-578.

https://doi.org/10.1097/00002030-200108004-00008

Mbopi-Ke'ou, F., Gre'senguet, G., and Mayaud, P., (2000). Interactions between herpes simplex virus type 2 and human immunodeficiency virus type infection in African women: opportunities for intervention. Journal of infectious diseases 182:1090-6.

https://doi.org/10.1086/315836

Nagot, N., Ouangre, A., Ouedraogo, A., Cartoux, M., Huygens, P., Defer, M.C Zekiba I. (2002). Spectrum of commercial sex activity in Burkina Faso: classification model and risk of exposure to HIV Journal of acquired immune deficiency syndromes and human retro virology 29:517-21.

https://doi.org/10.1097/00042560-200204150-00013

National Population Commission, National Population Census, 2006.

Oni, A.A., Adu, F.D., and Ekweozor, C.C. (1994).Isolation of herpes simplex Virus from sexually transmitted disease clients in Ibadan Nigeria. Journal of sexual transmitted diseases 21:187-90,

https://doi.org/10.1097/00007435-199407000-00001

Rathore, S., Jamwal, A., and Gupta, V. (2010). Herpes Simplex Virus type 2; Seroseroprevalence in antenatal women. Indian journal of sexual transmitted diseases 31:11-15.

https://doi.org/10.4103/0253-7184.68994

Riedner, G., Rusizoka, M., and Hoffthann 0, (2003). Baseline survey of sexually. Transmitted infections in a cohort of female bar workers in Mbeya Region, Tanzania. Journal of sexual transmitted infections, 79:382-7.

https://doi.org/10.1136/sti.79.5.382

Sani, N. M., E. D. Jatau, O. S. Olonitola, M. Y. Gwarzo, P. Moodley, and N. S. Mujahid (2015). Effect of Zidovudine on Hematological and Virologic Parameters among Female Sex Workers Receiving Antiretroviral Therapy (ART) in North - Western Nigeria. International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering, International Scholarly and Scientific Research & Innovation 9(5):432 - 437.

Vallely, A., Hambleton, I.R., Kasindi, S., Louise, K., Francis, S.C., Chirwa, T., Hayes, R.J. (2010). Are women who work in bars, guesthouses and similar facilities a suitable study population for vaginal microbicide trials in Africa? .FLoS One, 5(5),10661.

https://doi.org/10.1371/journal.pone.0010661

Wald, A. (2004) Herpes simplex virus type 2 transmission: risk factors and virus shedding. Herpes: the journal of IHMF 11:13 0A-7.

Wald, A., and Link, K (2002).Risk of human immunodeficiency virus infection in herpes simplex virus type-2 seropositive persons: a meta-analysis. Journal of infectious diseases 185:45-51.

https://doi.org/10.1086/338231

Weiss, H. (2004).Epidemiology of herpes Simplex Virus Type-2 infections in the developing world. Herpes: the journal of the International Healthcare Management Forum H: 24A-3 5A.

WHO. (200l). Herpes Simplex Virus type-2 pragmatic research priorities in developing countries: Geneva: Report of a WHO/UNAIDS/LSHTM Workshop, London p. 1-20.

Yusuf, Agabi., Edmund, B., Banwat, John, D., Mawak, Patricia, M., Lar, Nanma, Dashe, Michael, M., Dashen, Moses, P., Adoga, Felicia, Agabi, Hashimu Zakari. (2010), Seroseroprevalence of herpes simplex virus type-2 among clients attending the Sexually Transmitted Infections Clinic in Jos, Nigeria. Journal of infections 4(9):572-575.

https://doi.org/10.3855/jidc.567

Downloads

Published

30-06-2019

How to Cite

Sani, N. M., Rukayya, H.M., Ubandoma, M.S., Mujahid, N.S., Oni, M.A., & Isaka, I. (2019). Seroprevalence of Anti HSV-2 IgG among Women of Reproductive Age attending General Hospital Dutse. UMYU Journal of Microbiology Research (UJMR), 4(1), 1–5. https://doi.org/10.47430/ujmr.1941.001