Effects of Antibiotics on the Development and Colonization of Preterm Gut Microbiota: A Short Review
DOI:
https://doi.org/10.47430/ujmr.1832.018Keywords:
Antibiotics, Colonization, Gut, Microbiota, Neonate and PretermAbstract
The gut microbiota plays a vital role in the development of the immune system, nutrient absorption, and resistance to pathogen colonization. Antibiotics are among the many factors that affect and influence the establishment of the microbiota., Neonates, particularly those born prematurely, represent an interesting population because they receive early and often extensive antibiotic therapy in the first year of life. It is important to understand the effects of these antibiotics in reshaping and colonization of intestinal microbiome. Antibiotic therapy in preterm infants can dramatically affect the gut microbiome. Early establishment of the gut microbiome is suspected to have a particularly profound impact in protecting the gut from infectious disease and on long-term subsequent health by predisposing individuals to atopic or autoimmune disease later in life. This review gathers relevant literatures on the effects of antibiotics on the preterm gut microbiota both on their composition and development. This review indicates that some antibiotic treatments are associated with decreased species richness and diversity. Treatment with antibiotic encouraged resistance genes and proliferation of multidrug resistant organisms. Antibiotics regimens bring about population shifts and reshape the abundant microbial colonization. We therefore, demonstrated the impact of antibiotics on the composition of microbial community and its establishment from the gut of preterm infants during their early days of life.
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Gasparrini, A. J., Crofts, T. S., Gibson, M. K., Tarr, P. I., & Warner, B. B. (2016). Antibiotic perturbation of the preterm infant gut microbiome and resistome. Gut Microbes, 7(5), 443-449. https://doi.org/10.1080/19490976.2016.12 18584
https://doi.org/10.1080/19490976.2016.1218584
Gibson MK, Crofts TS, Dantas G. Antibiotics and the developing infant gut microbiota and resistome. Curr Opin Microbiol 2015; 27:51-6; PMID:26241507; http://dx.doi.org/10.1016/j.mib.2015.07.007
https://doi.org/10.1016/j.mib.2015.07.007
Gosalbes MJ, Llop S, Valles Y, Moya A, Ballester F, Francino MP. Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants. Clin Exp Allergy 2013;43:198e211.
https://doi.org/10.1111/cea.12063
Greenwood, C., Morrow, A. L., Lagomarcino, A. J., Altaye, M., Taft, D. H., Yu, Z., … Schibler, K. R. (2014). Early Empiric Antibiotic Use in Preterm Infants Is Associated with Lower Bacterial Diversity and Higher Relative Abundance of Enterobacter. The Journal of Pediatrics, 165(1), 23-29.https://doi.org/10.1016/j.jpeds.2014.01.0 10
https://doi.org/10.1016/j.jpeds.2014.01.010
Gritz, E. C., & Bhandari, V. (2015). The human neonatal gut microbiome : a brief review, 3(March). https://doi.org/10.3389/fped.2015.00017
https://doi.org/10.3389/fped.2015.00017
Groer, M. W., Luciano, A. A., Dishaw, L. J., Ashmeade, T. L., Miller, E., & Gilbert, J. A. (2014). Development of the preterm infant gut microbiome : a research priority, 1-8. https://doi.org/10.1186/2049-2618-2-38
https://doi.org/10.1186/2049-2618-2-38
Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Brandt, P. A. Van Den, … Kummeling, I. (2008). Factors Influencing the Composition of the Intestinal Microbiota in Early Infancy. https://doi.org/10.1542/peds.2005-2824
https://doi.org/10.1542/peds.2005-2824
Tanaka, M., & Nakayama, J. (2017). Allergology International Development of the gut microbiota in infancy and its impact on health in later life. Allergology International, 66(4), 515-522. https://doi.org/10.1016/j.alit.2017.07.010
https://doi.org/10.1016/j.alit.2017.07.010
Willing, B. P., Russell, S. L., & Finlay, B. B. (2011). F O C U S O N M U C O S A L M I C R O B I O LO G Y Shifting the balance : antibiotic effects. Nature Publishing Group, 9(4), 233-243.https://doi.org/10.1038/nrmicro2536
https://doi.org/10.1038/nrmicro2536
Yieh, C., Chong, L., & Bloomfield, F. H. (2018). Factors Affecting Gastrointestinal Microbiome Development in Neonates, 1- 17. https://doi.org/10.3390/nu10030274
https://doi.org/10.3390/nu10030274
Zhu, D., Xiao, S., Yu, J., Ai, Q., He, Y., & Cheng, C. (2017). Effects of One-Week Empirical Antibiotic Therapy on the Early Development of Gut Microbiota and Metabolites in Preterm Infants, (July 2016), 1-10. https://doi.org/10.1038/s41598-017-
https://doi.org/10.1038/s41598-017-08530-9
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