Evaluation of the Haematological Profile of Children Under Five (5) Years Infected with Malaria Attending Murtala Muhammad Specialist Hospital, Kano-Nigeria
DOI:
https://doi.org/10.47430/ujmr.2271.015Keywords:
Malaria, Children, Morbidity, Haematological profileAbstract
Malaria is a serious public health concern worldwide, particularly in hyper endemic areas of tropical and subtropical regions, including Nigeria. This study investigated haematological profile of children under five (5) years infected with malaria attending Murtala Muhammad Specialist Hospital, Kano-Nigeria. Venous blood was aseptically collected from the ante-cubital vein. Thick and thin blood films were prepared and viewed under a light microscope to identify and quantify the malaria parasites. The study involved 160 children randomly selected: comprising of 80 malaria positive and 80 negative children. Full blood count was estimated using SYSMEX auto-hematology analyzer (Lincolnshire, Illinois U.S.A.). The results showed that red blood cells were statistically lower in malaria infected (3.64±1.09×106/µL) compared to the controls (4.16±0.86×106/µL). Haemoglobin concentration (HGB) of malaria infected children was also lower (8.78±3.14g/dl) than that of the control group (10.56±2.33g/dl). Similarly, hematocrit percentage of the infected children was significantly lower (25.58±6.28%) compared to the controls of (27.03±7.35%). The platelet count (PLT) of the malaria children were also lower in the case group (172.27±120.65×103/µL) compared to the controls with (240.73±143.23×103/µL), (P>0.05). While the total White Blood Cell counts (WBC) and its differentials did not show any statistically significant difference between the malaria infected and the controls (p>0.05). This study clearly demonstrated that malaria significantly affects the haematological profile of children under five years of age leading to anemia and thrombocytopenia, with no effects on the white blood cells and differentials.
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References
Abdalla, S.H., and Pasvol, G. (2004). Malaria: A Hematological Perspective, Volume 4. London, UK: Imperial College Press.
Abdalla, S.H. (1988). Peripheral blood and bone marrow leucocytes in Gambian children with malaria: Numerical changes and evaluation of phagocytosis. Annals of Tropical Paediatrics 8(4):250-258.
https://doi.org/10.1080/02724936.1988.11748582
Adedotun, A. A., Salawu, O. T., Morenikeji, O. A. and Odaibo A. B. (2013) Plasmodial infection and haematological parameters in febrile patients in a hospital in Oyo town, South-western Nigeria. Journal of Public Health and Epidemiology 5(3):144-148.
Akhtar, S., Gumashta, R., Mahore, S., and Maimoon, S. (2012). Hematological changes in malaria: A comparative study. IOSR Journal of Pharmacy Biological Science; 2(4):15-19.
https://doi.org/10.9790/3008-0241519
Arévalo-Herrera M, Rengifo L, Lopez-Perez M, Arce-Plata MI, García J, Herrera S (2017) Complicated malaria in children and adults from three settings of the Colombian Pacific Coast: A prospective study. PLoS ONE 12(9)
https://doi.org/10.1371/journal.pone.0185435
Awoke N, Arota A. (2019) Profiles of hematological parameters in Plasmodium falciparum and Plasmodium vivax malaria patients attending Tercha General Hospital, Dawuro Zone, South Ethiopia. Infection and Drug Resistance 5 (12):521-527.
https://doi.org/10.2147/IDR.S184489
Bakhubaira S (2013). Hematological parameters in severe complicated Plasmodium falciparum malaria among adults in Aden. Turkish Journal of Hematology. 30:394-399.
https://doi.org/10.4274/Tjh.2012.0086
Balarajan, Y., Ramakrishnan, U., and Özaltin, E. (2011). Anemia in low-income and middle-income countries. Lancet 378: 2123-2135.
https://doi.org/10.1016/S0140-6736(10)62304-5
Bawah, A.T., Nyakpo, K.T., Ussher, F.A., Alidu, H., Dzogbo J.J. et al., (2018). Hematological profile of children under five years with malaria at the Ho Municipality of Ghana. Edorium Journal of Pediatrics 2018;2:100004P05.
Bidaki, Z., and Dalimi, A. (2003). Biochemical and hematological alteration in vivax malaria in Kahnouj city. Journal of Rafsanjan University of Medical Sciences. ;3:17-24
Camila, M., Chaparro, Parminder S. And Suchdev (2019) Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries. Annals of the New York academy of sciences; 1450(1): 15-31.
https://doi.org/10.1111/nyas.14092
Clark, I.A., Budd, A.C., Alleva, L.M., and Cowden, W.B (2006). Human malarial disease: A consequence of inflammatory cytokine release. Malaria journal; 10;5:85.
https://doi.org/10.1186/1475-2875-5-85
Conroy A. L, Datta D, John C. C. (2019). What causes severe malaria and its complications in children? Lessons learned over the past 15 years. BMC Medicine. 17(1):52.
https://doi.org/10.1186/s12916-019-1291-z
Faga D C, Obisike V U, Onah I E and Amuta E U. (2020). Assessment of Malaria Parasitemia and Genotype of Patients attending two Hospitals in Benue State, Nigeria. Animal Research International 17(2): 3640 - 3648
Jiero S., and Pasaribu AP. (2021). Haematological profile of children with malaria in Sorong, West Papua, Indonesia. Malaria Journal. 4;20(1):126.
https://doi.org/10.1186/s12936-021-03638-w
Kassa D, Petros B, Messele T, Admassu A, Adugna F, et al., (2005). Parasito-haematological features of acute Plasmodium falciparum and P. vivax malaria patients with and without HIV co-infection at Wonji Sugar Estate, Ethiopia. The Ethiopian Journal of Health Development 19(2):132-139.
https://doi.org/10.4314/ejhd.v19i2.9982
Morakinyo, O.M., Balogun, F.M., and Fagbamigbe, A.F (2018). Housing type and risk of malaria among under-five children in Nigeria: evidence from the malaria indicator survey. Malaria Journal; 17(1):1. doi:10.1186/ s12936-018-2463-6
https://doi.org/10.1186/s12936-018-2463-6
Muwonge, H., Kikomeko, S., Sembajjwe, L.F., Seguya, A. and Namugwanya, C. (2013). How reliable are hematological parameters in predicting uncomplicated Plasmodium falciparum malaria in an endemic region? ISRN Tropical Medicine :1-9.
https://doi.org/10.1155/2013/673798
Ntenda, P.A.M., Chilumpha, S., Mwenyenkulu, E.T. et al. (2019). Clinical malaria and the potential risk of anaemia among preschool-aged children: a population-based study of the 2015-2016 Malawi micronutrient survey. Infectious Diseases of Poverty 8, 95
https://doi.org/10.1186/s40249-019-0607-8
Oluwaseun, B.A., Zary S.Y. and Meor. F. (2021). Prevalence, Parasite Density and Determinants of Falciparum Malaria among Febrile Children in Some Peri-Urban Communities in Southwestern Nigeria: A Cross-Sectional Study. Infection and Drug Resistance. 14 3219-3232
https://doi.org/10.2147/IDR.S312519
Rasheed, A., Saeed, S. and Khan, S. (2009). Clinical and laboratory findings in acute malaria caused by various Plasmodium species. Journal of Pakistan Medical Association 59:220.
Xin-zhuan S, Cui Z, and Deirdre A J. (2020) Host-Malaria Parasite Interactions and Impacts on Mutual Evolution. Frontiers in Cellular and Infection Microbiology.
Vivier, E., Raulet, D.H, Moretta, A., et al. (2011). Innate or adaptive immunity? The example of natural killer cells. Science 7;331(6013):44-49.
https://doi.org/10.1126/science.1198687
Waris R, Aurengzeb B, Raza SH, Waris A, and Riaz R. (2021) Clinical Profile and Spectrum of Complications of Malaria in Hospitalized Children at a Tertiary Care Hospital. Journal of Rawalpindi Medical College 25(4): 516-520
https://doi.org/10.37939/jrmc.v25i4.1752
White, N.J. (2018): Anaemia and malaria. Malaria Journal 17(1):371.
https://doi.org/10.1186/s12936-018-2509-9
Wickramasinghe, S.N., and Abdalla, S.H (2000). Blood and bone marrow changes in malaria. Baillieres Best Practice and Research in Clinical Haematology;13(2):277-299.
https://doi.org/10.1053/beha.1999.0072
World Health Organization. 2015. Malaria Microscopy Quality Assurance Manual. Geneva: World Health Organization (2009). World Health Organization (WHO). World Malaria Report.
World Health Organization (2020). World Malaria Report: 20 Years of Global Progress and Challenges. Geneva: World Health Organization; 2020
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